Effect of intestinal function-recovering decoction on treatment of multiple organ dysfunction syndrome in rats

摘要

Objective:To analyze the effect of intestinal function-recovering decoction on multiple organ dysfunction syndrome in rats, and to investigate a novel solution to multiple organ dysfunction syndrome.Methods:Multiple organ dysfunction syndrome was induced in60Sprague-Dawley rats by intestinal ischemia-reperfusion combined with cecal ligation and puncture.Then these rats were intragastrically administered physiological saline(groupⅠ,n=20), ampicillin (groupⅡ,n=20) or intestinal function-recovering decoction(groupⅢ,n=20).After treatment, serum malondialdehyde and superoxide dismutase levels were compared among three groups. Simultaneously, bacterial culture of various organ tissues was performed and bacterial and endotoxin translocation were observed.Results:Compared with groupI, serum malondialdehyde, alanine aminotransferase and aspartate aminotransferase levels were significantly decreased(all P<0.05) and serum superoxide dismutase level was significantly increased(P<0.05) in the groupⅢ. However, there were no significant differences in these indices between groupsⅡ andⅢ(P>0.05). The rate of bacterial translocation in the groupsⅡ andⅢ was significantly lower than in the groupⅠ(P<0.05), and no significant difference was observed between groupsⅡ andⅢ(P>0.05). Conclusions:Intestinal function-recovering decoction can significantly reduce endotoxin and bacterial translocation and stabilize enteral oxidative-antioxidative balance.