Effect of simvastatin on expression of IL17, HMGB1 and TLR4 in LN kidney tissues of rats

摘要

Objective:To observe the intervention influence and effect of simvastatin on the expression of interleukin17(LI17), high mobility group protein1(HMGB1) andTLR4 path inLupus nephritis (LN) rats.Methods:A total of28BSXSB male mice withLN(16 weeks) were randomly divided into observation group and the comparison group, observation group was given6 mg•kg-1•d-1 simvastatin in0.1%PBS lavage for4 weeks, the comparison group was not given any treatment. Blood urea nitrogen(BUN) level and urine trace albumin(Scr) level of two groups were determined. The expression ofIL17,HMGB1 andTLR4 protein was detected using immune histochemical method, and the kidney histological damage was observed.Results:BNU,LI17,HMGB1,TLR4 protein andHMGB1 mRNA in observation group was significantly lower than that in control group (P<0.05);There was no statistical difference ofScr level between two groups(P>0.05).Histological observation showed glomerular lesions integral of observation group was obviously lower than that of control group.Conclusions:Simvastatin can reduce the expression ofIL17,HMGB1 and TLR4 protein inLN mice, thereby can inhibit the autoimmune response as a potential treatment function ofLN.