Effect of sevoflurane on tissue permeability of lung ischemia-reperfusion injury in rats

摘要

Objective: To investigate the effect of sevoflurane on tissue permeability of lung ischemia-reperfusion injury (LIRI) in rats. Methods: A total of 45 wistar rats were randomly divided into 3 groups Ⅰ, Ⅱ, Ⅲ. Modified Eppinger method was adopted to establish the rat lung ischemia-reperfusion injury model. GroupⅠ served as the control group, group Ⅱ as ischemia reperfusion group, group Ⅲ as sevoflurane ischemia-reperfusion group. Blood gas index, lung permeability index (LPI) change, lung tissue pathology change and lung water content were observed and compared between groups of rats at different time points. Results: During ischemia reperfusion, all rats kept balance of the MAP during different time points, SPO2 of group Ⅱ and Ⅲ decreased significantly than Ⅰ group (P<0.05); after reperfusion lung permeability index in Group Ⅱ andⅢ was higher than the control group significantly (P<0.05), 120 min after reperfusion LPI change and injury of group Ⅲ was significantly lower than Ⅱ group (P<0.05); interstitial and alveolar cavity effusion in of group Ⅲ were lower than that of group Ⅱ. Conclusions: Sevoflurane pretreatment can reduce the lung tissue permeability, and LIRI plays a protective role in LIRI.