Objective: To identify the bioactive potential of crude methanolic extracts of five gastropods and one bivalve collected from the west coast of India (Mumbai coast). Methods: Disc-diffusion assay and micro-dilution technique were used to test the bioactive potential of these molluscs against six pathogenic bacteria. Results: The crude methanolic extracts of all the molluscs showed significant activity against one or more bacteria tested. Minimum inhibitory concentration of crude methanolic extracts was found in the range of 0.10–0.35 mg/mL against human pathogenic bacterial strains. Hemifusus pugilinus and Nerita sp. extracts were most effective showing activity against all bacterial strains. Hemifusus pugilinus extract exhibited good activity against Vibrio cholerae contrary to earlier reports. Methanolic extract of Gafrarium divaricatum demonstrated considerable activity against both Escherichia coli and Streptococcus pyogenes. Trochus radiatus extract was inactive against all the bacteria tested except Escherichiacoli. Euchelus asper extract was active against Klebsiella pneumoniae and Pseudomonas aeruginosa. Conclusions: All the molluscs screened exhibited potential activity against one or more bacterial strain. Further work is in progress to isolate the active constituents of the extracts.
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