Objective To analyze the epidemiological trend of hepatitis B from 1990 to 2012 in Guangxi,to find the high risk populations and explore the further control strategies. Methods Based on the routine reporting incidence data of hepatitis B and demographic data of Guangxi we analyzed the incidence rates and sex-specific, age-specific incidence rates of hepatitis B by the simple linear regression model. Results A total number of 581 727 hepatitis B cases were reported, and the annual average morbidity was 56.78 per 100 000 during 1990 to 2012. The incidence of male (75.03 per 100 000)was higher than that of female (36.56 per100 000).The annual incidence rate of hepatitis B indicated an increasing trend for the whole population, while a decreased trend for the 0-9 year-old children in the past 23 years. The average age of hepatitis B onset increased yearly. Conclusion Young adult men are the key groups for the onset of hepatitis B. Besides improving the neonatal hepatitis B vaccination rates to block mother-to-child transmission we should strengthen the vaccination of the other high-risk populations.%目的：分析广西1990—2012年乙型肝炎发病的流行趋势，发现重点人群，进一步探讨防治策略。方法根据历年乙肝报告的发病资料和人口资料，计算年发病率以及性别、年龄别发病率，并建立简单线性回归模型进行统计分析。结果1990—2012年广西共报告乙肝发病581727例，年平均发病率为56.78/10万，男性发病率（75.03/10万）高于女性（36.56/10万）；总体发病率呈上升趋势，但0～9岁年龄组呈显著下降趋势；平均发病年龄呈后移趋势，20～29岁人群发病率最高。结论男性青壮年为乙肝发病的重点人群，预防乙肝应在提高对新生儿乙肝疫苗接种率和阻断母婴传播的基础上，加强对其他人群尤其是高危人群的接种工作。
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