miR-300靶向apaf1降低电离辐射引发p53突变型肺癌细胞的凋亡

摘要

microRNAs(miRNAs)play important roles in the cellular response to ionizing radiation(IR)through regulating key mediators of DNA damage response pathways,such as ATM[1]and ATR[2].It has been revealed that miR-300 is involved in the cellular chemo-and radio-resistance in ovarian and gastric cancers[3,4].In recent study,we found that miR-300 abrogated IR-induced G2 cell cycle arrest in human lung cancer cells through targeting p53[5].However,the effects of miR-300 on the cellular sensitivity to IR in p53 mutant cells still need further investigation。