High-linear energy transfer(LET)heavy ions produce more cytotoxic and genotoxic damage to cells in comparison with low-LET ionizing irradiation,such as X-rays or-rays[1].Our previous studies demonstrated that exposure to heavy ions such as carbon ions caused decrease in testicular weight and sthenospermia,which affects the testicular development and breeding activity of males.The reason is that the organ systems with proliferating cells are very sensitive,and the testis is a radiosensitive organ.Additionally,in space travel,astronaut exposed to high-LET galactic cosmanic rays at higher radiation doses and dose rates than humans received on Earth.It is an unavoidable problem for long duration manned interplanetary missions.Furthermore,in hadrontherapy,although high-LET heavy ions as an innovative modality of high precision tool for the treatment of cancer such as testis and prostate tumor,potential damage to healthy tissues surrounding the tumor target along its penetrating path should still be considered.Given space radiation protection and cancer therapy,there is a demand for reliable agent for protection of the testis against heavy-ion radiation.
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