3-57 Protective Effect of Diallyl Disulfide on Carbon Ion Irradiation-induced Cell Death in Mouse Testis via p73 Signaling Pathway, But Not p53

摘要

Diallyl Disulfide (DADS) is the main organosulfur component of garlic and it is known for multiple pharmacologicalactions. Currently, DADS has been well documented to ameliorate the testis injuries caused by X-rayirradiation[1??4]. However, the effect of DADS against heavy-ion-induced testis damage, particularly cell apoptosis,is still largely unknown. In this regard, based on ground experiments at accelerators, this study has been undertakento estimate the protective mechanisms of DADS against carbon ion-induced cell apoptosis at the level ofsignal transduction pathway in mouse testis.