One of the main engines that drive cellular transformation is the loss of proper control of the cell cycle. Thecyclin-dependent kinase inhibitor p21 (also known as p21WAF1/Cip1) promotes cell cycle arrest in response tomany stimuli[1]. Our recent study[2;3] showed that a global and stable cell cycle block was established in 92-1 cellsafter 10 Gy of X-ray and carbon ion irradiation and cells underwent senescence 5 d later. p21 was detected at highlevels from 4 h to 5 d after irradiation in these cells, which implied that p21 played a crucial role in cellular responseto irradiation.
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