3-72 Early Embryonic Exposure of Ionizing Radiation Disrupts Zebrafish Pigmentation

摘要

Mitochondrial F1F0-ATPase has been shown to modulate pigmentation negatively in zebrafish[1;2]. Both of these works hypothesize that the alkalization of cellular endomembrane system, as induced by inhibition of mitochondrial ATPase-mediated transport of H+ ions, facilitates trafficking of Tyr to the melanosomes that enhance zebrafish pigmentation.Wang[3] et al. further identified that Beta adrenergic receptors ( -ARs) regulate zebrafish pigmentation partly by modulating F1F0-ATPase. These studies suggest the important role of mitochondrial F1F0-ATPase in zebrafish pigmentation, but whether IR could affect F1F0-ATPase function has not been studied.