Effects of Sub-chronic Intoxication of 1, 8-cineole on Blood Biochemical Indexes of Mice

摘要

[Objective] Effects of sub-chronic intoxication of 1,8-cineole on body weights,routine blood indexes and biochemical indexes of mice were investigated. [Method] One hundred and sixty mice with body weights of 15- 17 g were randomly divided into four groups( forty mice per group). Mice were injected to1,8- cineole with doses of 192. 45,64. 15 and 21. 38 mg / kg body weight( test groups) and the water solution of tween-80 with a volume fraction of 0. 5%( control group) respectively. Each mouse was administered orally at the dose of 0. 2 m L per 10 g body weight once a day consecutively for 90 d. The body weight,routine blood indexes and serum biochemical indexes of mice were determined on the 30 thd,60thd,90 thd and the 30 thd after stopping the administration of 1,8-cineole.[Result]The effects of 1,8-cineole on the body weight,routine blood indexes and serum biochemical indexes of mice with the doses of 64. 15 and 21. 38 mg/kg body weight had no statistically significant difference compared with the control group( P > 0. 05). 1,8-cineole with the dose of 192. 45 mg / kg body weight exhibited different influences on routine blood indexes and serum biochemical indexes of mice after the oral administration of 1,8-cineole for 60 d and 90 d,and statistically significant differences in many blood biochemical indexes were observed( P 0. 05).[Conclusion]1,8-cineole had sub-chronic oral toxicity to mice. The no observed adverse effect level( NOAEL) of 1,8-cineole was 64. 15 mg/kg body weight and the lowest observed adverse effect level( LOAEL) of 1,8-cineole was 192. 45 mg / kg body weight. Effects of 1,8-cineole on blood biochemical indexes of mice were in short term and reversible.