Objective To observe the effect of Dl-fu kidney-tonifying granule of TCM on osteoporosis in rats with deficiency of the kidney. Methods 72 female of SD rats were divided into 6 groups: Sham, Model, Positive( dose of 0. 27 g · kg-1 ), High dose group( 11.72 g · kg-1),Medium dose group( 5. 86 g · kg-1 ),Low dose group( 2. 93g · kg-1)of Dl-fu kidney-tonifying granule. There were 12 mice in each group, except the Sham, the remaining groups were executed orariectomy to establish osteoporosis model. After 8 weeks, the results of every group were observed, compared and analyzed. Results Dl-fu kidney-tonifying granule of TCM could significantly promote the level of Uterus' index, BMD, Ca2+ , E2 on osteoporosis in rats with deficiency of the kidney, reduce the ratio of high divert of bone by decreasing the activity of TLAP and ALP,decrease the expression of IL-6. Conclusion Dl-fu kidney-tonifying granule of TCM has effects on osteoporosis in rats with deficiency of the kidney by tonifying the kidney.%目的 观察地附补肾颗粒对肾虚致骨质疏松模型大鼠的实验影响.方法 将72只SD雌性大鼠随机分为6组:假手术组、模型组、阳性对照组(0.27g·kg-1)、地附补肾颗粒高(11.72 g·kg-1)、中(5.86 g·kg-1)、低(2.93 g·kg-1)组,每组12只,除假手术组,其余各组去势法切除双侧卵巢复制骨质疏松模型.造模后用药组给药8周,之后观察各组结果并作比较分析.结果 地附补肾颗粒中剂量能显著提升骨质疏松模型大鼠的子宫指数、BMD、Ca2+、E2水平,通过降低TRAP、ALP活性降低骨高转换率,降低IL-6的表达.结论 地附补肾颗粒通过补肾滋阴,可改善肾虚致骨质疏松模型大鼠的症状.
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