不同非密闭雾化治疗方式在不合作患儿中的应用效果

摘要

目的：探讨不同非密闭雾化方式在不合作患儿接受布地奈德雾化治疗中的应用效果。方法选取本院门诊270例3岁以下使用布地奈德雾化治疗的患儿,采用随机数字表法将患儿分为 Pari 雾化系统、Philips 雾化系统及 Salter 雾化系统3个治疗组,毎组90例,各组又依据面罩距离面部0 cm、2 cm、4 cm 分为3个小组,毎组30例,分别测量各组雾化气流流速及吸入雾化颗粒量占总雾化颗粒量的比例。采用方差分析及 Bonferroni 进行统计分析。结果雾化气流流速及雾化吸入量在不同雾化系统组间差异有统计学意义(P <0．05)。在3种距离下,Pari 系统均能使患儿吸入最多量的雾化颗粒,其次是 Salter 系统,再是 Philips 系统,与此相反,气流流速 Pari 系统最低。 Pari 系统离开面部4 cm 及 Salter 系统离开面部2 cm 的吸入量均高于 Philips 系统0 cm 的吸入量。结论选择合适的非密闭雾化系统方式,是提高不合作患儿布地奈德雾化治疗的有效方式。%Objective To explore the clinical effects of different blow-by nebulizertherapies on budesonide inhalation in the uncoop-erative children. Methods 270 cases of outpatient children(below 3 years old)ever treated with nebulized budesonide inhalation in our hos-pital were recruited into this study. Using the random number table,the children weredivided into 3 groups,90 cases in each group,and sepa-ratelytreated with Pari nebulizer,Philips system orSalter system;each group was then divided into 3 smaller groups(30 children per group) whose masks were set at 0 cm,2 cm or 4 cmfrom their faces,respectively. The nebulized flow speed and ratio of inhaled mass to total mass were detected,and the obtained datawereanalyzed byvariance analysis and Bonferroni test. Results The nebulized flow speed and inhaled mass differed significantly in 3 groups with different nebulizers(P < 0. 05). The Pari nebulizerr system delivered most inhaled mass at all 3 distances from faces,then came the Salter system,and the Philips system got the least. But the slowest nebulized flow speed was seen in the Pari system. The Pari nebulizer at 4cm and the Salter system at 2cm from faces delivered more inhaled mass than that of the Philips system at 0cm. Conclusion In the uncooperative children,choosing the appropriate blow-by nebulizer system is an effective way to improve the clinical effects of nebulized budesonide inhalation therapy.