Hemostatic Effect of Chitosan-based Fiber

摘要

Abstract [Objective] The aim was to investigate the hemostatic effects of chitosan- based fibre on liver. [Method] The liver hemorrhage model of rabbit was established. Hemostasis was performed with chitosam-based fiber in experimental group, surgicel in control group and no material in blank group. The hemostatic effects were evalu- ated by total blood loss （TBL） and hemostatic rate. [Result] Experimental group had no bleeding in observation period, with the hemostatic rate of 100% and the blood loss of only （0.443_＋0.30） g/kg, better than the control group and blank group （P〈 0.005）. [Conclusion] Chitosan-based fiber has effective hemostasis in liver wound, which will provide reliable information for the clinical trials.