CR3和FcR在肝细胞癌中的分布特征

摘要

Objective To examine the distribution and character of macrophages in hepatocellular carcinoma ( HCC ). Methods The 14 cases data of HCC were collected. The expression and distribution of hepatic surface receptors CR3( CDllb/ CD18 )and FcR ( CD16 )in liver specimens were dectected by flowcytometry and immunohistochemical. Results Expression percents of macrophages CR3 and FcR in HCC were significantly lower than that in the adjacent peritumoral tissues( P ＜ 0. 01 ). Immunohistochemical analysis showed CR3 and FcR stained brown in the cytoplasm of macrophages, with continuous or focal granular distribution. Conclusion Expression and distribution of macrophages surface receptors CR3 and FcR in HCC tissues are lower than that in the adjacent peritumoral tissues, which may be related to decrease resistance of tumor.%目的 检测巨噬细胞表面受体在肝细胞癌中的分布特征.方法 收集14例肝细胞癌患者资料.利用流式细胞仪和免疫组化SP法检测肝脏标本巨噬细胞表面受体CR3和FcR的表达量,了解巨噬细胞表面受体在肝组织中的位置及分布情况.结果 癌组织中巨噬细胞表面受体CR3和FcR表达量明显少于癌旁组织 (P<0.01).CR3和FcR着色于巨噬细胞,胞浆呈棕黄色,连续或灶性颗粒状分布.结论 巨噬细胞表面受体表达量CR3和FcR在肝癌组织分布及表达少于癌旁组织,导致组织抗肿瘤能力低下.