不同程度神经功能缺损的脑梗死患者血尿酸与预后的相关性研究

摘要

根据美国国立卫生研究院卒中量表( NIHSS)评分将急性脑梗死患者分为轻度和中重度神经功能缺损两组,发病后第7 天行 NIHSS 评分,第 1 个月和第 3 个月行改良RANKIN量表( mRS)评分,检测发病24 h内和发病后第7天的血尿酸( SUA)浓度,分析SUA与神经功能评分的相关性.55例轻度神经功能缺损患者的SUA浓度无明显变化, SUA浓度与评分均无关;65例中重度神经功能缺损患者的SUA浓度显著降低,且SUA变化值与第7天NIHSS和第1个月mRS有关,Logistic回归显示SUA变化值是第1个月预后不良的危险因素.%According to the scores of the United States National Institutes of Health Stroke Scale ( NIHSS) , the pa-tients with acute cerebral infarction were divided into two groups with mild or moderate-severe neurological impair-ment. The NIHSS was completed in day7 and the modified RANKIN scale ( mRS) was done in month 1 and month 3 after onset of stroke. The concentrations of serum uric acie( SUA) were measured within 24 hours and day 7 after onset of stroke. The correlation between SUA and neurological scores was analyzed. Of the 55 patients with mild neurological impairment, no significant changes of SUA occurred and SUA concentrations were not related to neuro-logical scores. Of the 65 cases with moderate-severe impairment, the concentrations of SUA decreased significantly and the changes of SUA were correlated with the NIHSS in day7 and the mRS in month 1 . Logistic regression analy-sis showed that the change of SUA was the risk factor of poor prognosis in month 1 .