探讨受精后第2天(D2)行胚胎移植在低可利用胚胎患者体外受精或卵母细胞质内单精子显微注射(IVF/ICSI)周期的应用价值.选择接受WF/ICSI治疗、年龄<40岁且可利用胚胎数实3枚的患者作为研究对象,共191个周期;其中D2行胚胎移植99个周期(D2移植组),D3行胚胎移植 92个周期(D3移植组),比较D2与D3移植组以及D2移植与其既往D3移植组的临床结局.D2移植组的获卵数及胚胎耗损率均显著低于D3移植组(P<0. 05),优胚率显著高于D3移植组(P<0.05),但胚胎种植率、临床妊娠率、早期流产率及异位妊娠率均与D3移植组间差异无统计学意义. D2移植组的胚胎耗损率及周期取消率均显著低于既往D3移植周期(P<0.05),但胚胎种植率及临床妊娠率均显著高于既往D3移植周期(P<0. 05).对低可利用胚胎患者,选择D2行全胚胎移植不失为一个有价值、可供选择的胚胎移植策略.%To investigate the clinical value of post-fertilization day two (D2 ) embryo transfer for the patients with low available embryo. The data of 191 in vitro fertilization or intracytoplasmic sperm injection(IVF/ICSI) cycles in reproductive medicine center from Dec, with the enrolled criteria of the female's age less than 40 years old and available embryos number ≤ 3. The clinical outcomes of D2 embryo transfer (99 cycles) and day three (D3) (92 cycles) embryo transfer as well as D2 embryo transfer with its previous D3 embryo transfer were compared. With significant increase in the number of eggs and consumption rate of embryo in D2 group were significantly lower compared with those in D3 group (P < 0. 05 ). The optimal embryo rate was significantly higher than that of the D3 group (P < 0. 05). There were no significant difference in embryo implantation rate, clinical pregnancy rate, early abortion rate and ectopic pregnancy rate between D2 and D3 groups. By self-control, it was found that consumption rate of embryo and cycle cancellation rate in D2 transfer cycles were significantly lower than previous D3 transfer cycles (P < 0. 05), while the embryo implantation rate and clinical pregnancy rate in D2 transfer cycles were significantly higher compared with previous D3 transfer cycles (P < 0. 05 ). For low-availability embryos, selecting D2 for complete embryo transfer is a valuable alternative strategy.
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