复方血栓通胶囊基于血液循环和凝血过程相关靶点的网络药理学研究

摘要

利用基于计算机分子对接的网络药理学方法,研究复方血栓通胶囊化学成分对血液循环和凝血过程相关靶点的作用,并得到了成分对靶点的作用网络图.研究表明复方血栓通胶囊化学成分对ACE、PDE等多个靶点起作用.研究为在分子水平上揭示复方血栓通胶囊治疗视网膜静脉阻塞的多靶点调控机制提供了依据.%Network pharmacology based on the computational molecular docking was used to study interaction of chemical composition of Compound Xueshuantong Capsule to the targets related to blood circulation and hemostasis. A compound-target interaction network diagram was generated. The results showed that the chemical compounds of Compound Xueshuantong Capsule interacts with the multiple targets, such as ACE and PDE, revealing the multitargeted regulatory mechanism of Compound Xueshuantong Capsules in the treatment of retinal vein occlusion on molecular level.