黄芪总甙延缓衰老的作用及其机制

摘要

AIM: To study the anti-aging effect of astragalosides (AST) and its mechanism of action. METHODS: Rotatingrod test and step-down type passive avoidance test were performed to determine the effects of AST on motor andmemory of D-galactose (D-gal)-induced senescent mice and the middle-aged mice. The proliferative response ofsplenocytes induced by Con A or LPS, IL-2 production of splenocytes induced by ConA of D-gal-treated mice andthe middle-aged mice were also measured. RESULTS: AST (40 mg.kg-1.d-1, ig, for 10 weeks) was found toameliorate age-related alternations in both motor response and memory, enhance the deteriorated cellular immunityin D-gal-treated mice and the pre-aged (17-month-old) mice. CONCLUSION: AST has an anti-aging effecton D-gal-induced senescent mice and has the effect of delaying senility of the middle-aged mice, which was relatedto its improvement of brain function and immunomodulatory effects.%目的:研究黄芪总甙(astragalosides,AST)延缓衰老的作用及其机制.方法:采用小鼠D-半乳糖(D-galactose,D-aal)人工衰老模型和自然衰老模型(17月龄),以小鼠协调运动、学习记忆、以及免疫功能作为指标,同步观察药物的作用.结果:AST(40mg@kg-1@d-1,ig,10周)可明显恢复D-gal衰老小鼠的协调运动和学习记忆功能,使其过低的ConA诱导脾淋巴细胞增殖反应及IL-2产生明显升高,但对LPS诱导B淋巴细胞增殖反应无明显影响.AST(40mg@kg-1@d-1,ig,3个月)对17月龄小鼠亦有类似作用.结论:AST对D-gal衰老小鼠和由中年期(14月龄)进入老前期(17月龄)小鼠的自然衰老进程均有明显的延缓作用,可能与其免疫调节作用有关.