Department of Pharmaceutics;
Key Laboratory of Chemical Biology(Ministry of Education);
NMPA Key Laboratory for Technology Research and Evaluation of Drug Products;
School of Pharmaceutical Sciences;
Cheeloo College of Medicine;
Shandong University;
Jinan 250012;
China;
Nano-engager; Cold tumors; Increased DNA damage; Augmented immunogenic cell death; Dual immune checkpoint inhibition; BRD4 inhibition; Differ-targeting delivery; MMP-2 sensitive;