School of Pharmaceutical Sciences;
Sun Yat-sen University;
Guangzhou 510006;
China;
Research and Development Center of Pharmaceutical Engineering;
Sun Yat-sen University;
Guangzhou 510006;
China;
Zhong Yi Pharmaceutical Company Ltd.;
Guangzhou 510530;
China;
School of Mathematics&Computational Sciences;
Sun Yat-sen University;
Guangzhou 510275;
China;
Doxycycline; Hydroxypropy-β-cyclo-dextrin; Response surface methodology; Artificial neural network; Support vector machine; Genetic algorithm;