Characterization of a dextran–coated layered double hydroxide acetylsalicylic acid delivery system and its pharmacokinetics in rabbit

摘要

The aim of this study was to prepare a dextran–coated layered double hydroxide acetylsalicylic acid(DEX–LDH–ASA)delivery system by co-precipitation of LDH–ASA and its in-situ compositing with DEX.The structure of the system was investigated using X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FT-IR)and thermogravimetry(TG).Its in vitro drug release properties and in vivo pharmacokinetics in rabbit were also determined.The results show that the DEX–LDH–ASA system retained the crystal structure of LDH–ASA and gave a marked improvement in its dispersion.It also prolonged the release of ASA and shifted the release pattern from first-order to zeroorder kinetics.The pharmacokinetics of ASA administered in the DEX–LDH–ASA system to rabbits produced two absorption peaks with a Cmax of 14.871.7 mg/L at 2.1170.69 h and an elimination halflife of 2.2570.84 h for the first peak.The fact that delivery of ASA in the DEX–LDH–ASA system was sustained with improved bioavailability indicates the potential of the system as a controlled release formulation with application to other drugs.