纳米金属氧化物的神经毒性效应研究进展

摘要

Manufactured metal oxide nanomaterials are utilized in a wide variety of applications including in diagnostic devices, cell tracking, drug targeting and regenerative medicine, and their potential adverse effects on both the environment and human health have been concerned. It has been reported that metal oxide nanomaterials-induced reactive oxygen species(ROS)generation and cytokine release play important roles in the blood-brain barrier damage and central nervous system(CNS)dysfunction. However, the mechanism underlying metal oxide nanomaterials-related neurotoxicity has not been fully elucidated. Here, the neurotoxic effects of metal oxide nanoparticles on central nervous system are reviewed.%人造纳米金属氧化物材料因其独特理化特性，已被广泛应用于生物医药、细胞标记分选、药物载体和临床治疗等领域，其对人类健康和环境安全的影响日益受到关注。研究表明，纳米金属氧化物进入神经系统后，引起活性氧与细胞因子释放，导致血脑屏障损伤和中枢神经系统功能紊乱，但其毒性作用机制仍不清楚。本文综述了纳米金属氧化物的神经毒性效应及作用机制的相关研究进展。