Compatible endometrial receptivity is essential for successful implantation.The underlying molecular mechanisms are continuously explored in assisted reproduction field,focusing on the proteinencoding genes and microRNAs (miRNAs) [1,2].However,the effects of circular RNAs (circRNAs) on endometrial receptivity,as well as the regulatory mechanisms,are poorly understood.circRNAs are a special class of non-coding endogenous RNAs that have covalently closed continuous loops without a 5'cap or a 3'poly A tail [3].Interestingly,circRNAs are abundant,evolutionally conserved,and relatively stable in the cytoplasm,exhibiting tissue-,cell-,and developmental-stage-specific expression patterns [4].Growing evidence has confirmed that circRNAs are involved in a variety of biologic processes and play a role in the development of some diseases by acting as miRNA sponges or by modulating the expression of parental genes [5].
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