According to the data from WHO,there will be 2.16 billion overweight and 1.12 billion obese individuals in the world by the year 2030 [1],which raises the risk of multiple diseases,such as hypertension,diabetes,cardiovascular disease,and several types of cancer [2,3].Obesity is viewed as a metabolic disorder,which is mainly induced by high energy intake.In mammals,excess energy is primarily stored as triglyceride (TG) in adipose tissue.Over the past decades,numerous molecules that regulate the process of adipogenesis have been well documented.Peroxisome proliferator-activated receptor γ (PPAR-γ) is required for the accumulation of adipose tissue and contributes to obesity [4].Sterol regulatory element binding protein (SREBP) has been identified as a family of transcription factors that activate the entire program of cholesterol and fatty acid synthesis [5].Glyceraldehydes 3-phosphate acyltransferase (GPAT) and diacylglycerol acyhransferase (DGAT) are widely expressed in mammalian tissues and catalyze the first and final step in TG synthesis,respectively [6].Thus,these molecules may be great targets for the evaluation of obesity and lipid metabolism.
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