Increased GSK-3β expression in DRG microglia in response to sciatic nerve crush

摘要

Neuronal loss and apoptosis often occur in peripheral nerve injury,which is associated with release of inflammatory molecules and activation of microglia/macrophages [1].Excessive inflammatory response mediated by glial cells can exacerbate many neurological conditions and cause allodynia,hyperalgesia,neuropathic pain,and opioid tolerance [2].The Iba1-immunoreactive (IR) cells in the injured dorsal root ganglions (DRGs) can be intrinsic microglia and/or monocyte-derived macrophages,both of which are major sources of tumor necrosis factor-α and other inflammatory cytokines implicated in neuropathic pain syndromes.Thus,inflammatory modulation may provide a therapeutic solution for the treatment of these aforementioned diseases.