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Discovery and Development of Selective M1 Agonists that Protect Against Alzheimer's Pathology and Bias Hippocampal Circuitry Dynamics in Rodents

机译：选择性M1激动剂的发现和开发，可预防啮齿类动物的阿尔茨海默氏病和偏倚海马回路动力学

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作者
Lebois, Evan P.;
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作者单位

Emory University;

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授予单位 Emory University;
学科
学位 Ph.D.
年度 2014
页码 239 p.
总页数 239
原文格式 PDF
正文语种 eng
中图分类
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1. Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors. [J] . Messer WS Jr, Rajeswaran WG, Cao Y, Pharmaceutica acta Helvetiae . 2000,第2a3期

机译：用于治疗阿尔茨海默氏病的选择性毒蕈碱激动剂的设计和开发：四氢嘧啶衍生物的表征以及改善M1受体亲和力和选择性的新方法的开发。
2. Amelioration of Experimental Amnesia (Passive Avoidance Failure) in Rodents by the Selective M1 Agonist AF102B [J] . Fumio MIZOBE, Gosei KAWANISHI, Noboru NAKAHARA, Japanese Journal of Pharmacology . 1988,第4期

机译：选择性M1激动剂AF102B改善了啮齿动物的实验性失忆（被动回避失败）
3. Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice. [J] . Seo H, Ferree AW, Isacson O The European Journal of Neuroscience . 2002,第3期

机译：在正常小鼠中，胆碱能毒蕈碱拮抗剂或M1激动剂治疗可动态改变皮质海马APP和NGF的水平。
4. Effects of Alzheimer's pathology on memory function in a biophysical model of hippocampal CA3 [C] . Leif H. Finkel, Elliot D. Menschik IEEE Engineering in Medicine and Biology Annual Conference . 1999

机译：Alzheimer病理对海马CA3生物物理模型中记忆功能的影响
5. Alzheimer's disease (AD) like pathology following developmental lead exposure in primates and the role of aging in AD-related genes regulation in rodents and primates. [D] . Wu, Jinfang. 2008

机译：阿尔茨海默氏病（AD）类似于灵长类动物体内发育性铅暴露后的病理，以及啮齿动物和灵长类动物中衰老在AD相关基因调控中的作用。
6. Discovery of Novel N-SubstitutedOxindoles as Selective M1 and M4 MuscarinicAcetylcholine Receptors Partial Agonists [O] . Takaaki Sumiyoshi, *, †, 2013

机译：发现新的N取代羟吲哚作为选择性的M1和M4毒蕈碱乙酰胆碱受体部分激动剂
7. Amelioration of Experimental Amnesia (Passive Avoidance Failure) in Rodents by the Selective M1 Agonist AF102B [O] . Noboru NAKAHARA, Yoshinori IGA, Fumio MIZOBE, 1988

机译：通过选择性M1激动剂AF102B改善啮齿动物中的实验性敏捷（被动避免失败）的改善

Discovery and Development of Selective M1 Agonists that Protect Against Alzheimer's Pathology and Bias Hippocampal Circuitry Dynamics in Rodents

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