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The evolution of a fosfomycin resistance enzyme, FosA, from Pseudomonas aeruginosa and the development of a high-throughput screen for the discovery of bioactive inhibitors.

机译：铜绿假单胞菌对磷霉素抗性酶FosA的进化以及发现生物活性抑制剂的高通量筛选的发展。

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Abstract not available.

机译：摘要不可用。

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作者
Brown, Daniel Wade.;
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作者单位

Vanderbilt University.;

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授予单位 Vanderbilt University.;
学科 Biology Microbiology.;Chemistry Pharmaceutical.;Chemistry Biochemistry.
学位 Ph.D.
年度 2010
页码 148 p.
总页数 148
原文格式 PDF
正文语种 eng
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专利

1. Clinically relevant concentrations of fosfomycin combined with polymyxin B, tobramycin or ciprofloxacin enhance bacterial killing of Pseudomonas aeruginosa, but do not suppress the emergence of fosfomycin resistance [J] . Walsh Clare C., Landersdorfer Cornelia B., McIntosh Michelle P., The Journal of Antimicrobial Chemotherapy . 2016,第8期

机译：临床相关浓度的磷霉素与多粘菌素B，妥布霉素或环丙沙星合用可增强铜绿假单胞菌的细菌杀灭作用，但不能抑制磷霉素耐药性的出现
2. Image-based 384-well high-throughput screening method for the discovery of skyllamycins A to C as biofilm inhibitors and inducers of biofilm detachment in Pseudomonas aeruginosa [J] . NavarroG., ChengA.T., PeachK.C., Antimicrobial agents and chemotherapy. . 2014,第2期

机译：基于图像的384孔高通量筛选方法，用于发现作为铜绿假单胞菌生物膜抑制剂和生物膜脱离的诱导剂的天生霉素A至C
3. High-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm development. [J] . Junker LM, Clardy J Antimicrobial agents and chemotherapy. . 2007,第10期

机译：高通量筛选铜绿假单胞菌生物膜发育的小分子抑制剂。
4. Development of resistance to chemical disinfection by pseudomonas aeruginosa during long-term space flight [C] . George L.Marchin, American Institute of Physics Conference on international space station utilization . 1999

机译：在长期空间飞行期间，假单胞菌铜绿假单胞菌的耐化学消毒抵抗力的发展
5. Combining virtual and high-throughput screening in the discovery of new cruzain inhibitors. [D] . Ferreira, Rafaela Salgado. 2010

机译：虚拟和高通量筛选相结合，发现了新的克鲁萨因抑制剂。
6. fosA3 overexpression with transporter mutations mediates high-level of fosfomycin resistance and silence of fosA3 in fosfomycin-susceptible Klebsiella pneumoniae producing carbapenemase clinical isolates [O] . Uthaibhorn Singkham-in, Netchanok Muhummudaree, Tanittha Chatsuwan 2020

机译：FOSA3带有转运蛋白突变的过表达介导高水平的FOSFOMYCIN抗性和沉默FOSSα3在FOSFOMCIN - 易感克莱布氏菌肺炎生产碳结构酶临床分离株
7. Functional analysis of active site residues of the fosfomycin resistance enzyme FosA from Pseudomonas aeruginosa [O] . Zanna Beharry, Timothy Palzkill 2014

机译：来自铜绿假单胞菌的磷霉素抗性酶Fosa的活性位点残基的功能分析

The evolution of a fosfomycin resistance enzyme, FosA, from Pseudomonas aeruginosa and the development of a high-throughput screen for the discovery of bioactive inhibitors.

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