We tested 203 healthy and affected Birman cats by genome wide association study (GWAS) and identified 27 SNPs associated with resistance to feline infectious peritonitis (FIP). Genes involved in innate and/or adaptive immune response were located near these SNPs. The SNPs were then used to test an additional 109 cats (total n = 312) with Sequenom assay. In the final analysis, six SNPs had very strong associations (p < 0.001), three SNPs had intermediate associations (p < 0.01), and nine SNPs were weakly associated with FIP (p < 0.05). However, no 100% penetrance was detected for individual SNP markers, suggesting that FIP is a complex disease and multiple genetic factors are involved in its pathogenesis.
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