Preparation, bioactivity, and application of novel biocidal materials.

摘要

In this study, several novel N-halamine precursors were synthesized. These surface coupling agents were bonded to the surfaces of cotton fabric, cotton gauze, paper, glass, and sand. Once they were activated using household bleach, the surfaces and materials became biocidal. Possible uses for the biocidal cotton are in protective garments for hospital personnel and those who must fight against bioterrorism. The treated cotton gauze may be used to make an antimicrobial mask to stop infective pathogen transcontamination. Biocidal sand has the potential to be used as a disinfectant in a filter for wastewater or municipal water treatment. In fact, the N-halamine siloxanes can be applied to many other surfaces. The results of biocidal efficacy of some of the treated surfaces will be presented in this study.; Several new hydantoinyl diols and quaternary ammonium hydantoinyl diols were prepared in this work also. They were copolymerized with commercial water borne acrylic polyol and commercial isocyanate to form polyurethane coatings. The biocidal polyurethane coatings were produced after activation by chlorination. Those diols also reacted with a two-component epoxy paint to render the paint antimicrobial.; Several novel biocidal polymeric resins were synthesized by attachment of N-halamine moieties to the commercial polymer supported beads such as Merrifield resin and Amberlite IRA-67 ionic resin. The Merrifield resin and Amberlite IRA-67 ionic resin also were grafted with N-halamine functionality as well as with the N,N-dimethyl-dodecylamine moiety via 1,2-dichloroethane.; Finally, several quaternary ammonium N-halamine polymers were prepared. Direct copolymerization of (triethoxysilyl)propyl-7,7,9,9-tetramethyl-1,3,8-triazaspiro-[4,5]-decane-2,4-dione (TTDD-Si), or 3-(trimethoxysilyl)propyl-5,5-dimethylhydantoin (BA-1 ') with 3-(trimethoxysilylpropyl)dimethyloctadecyl ammonium chloride (DC 5700) produced dual functionality and water soluble biocidal materials and surfaces. (Abstract shortened by UMI.)