The anti-tumour effects of apigenin in neuroblastoma.

摘要

Neuroblastoma is a highly aggressive paediatric tumour of the peripheral nervous system, accounting for 15% of childhood cancer deaths. Despite current treatment protocols, most patients develop drug resistance and present with tumor recurrence, metastasis and exhibit poor survival rates. Therefore, development of more effective, less toxic therapies is warranted. Apigenin, a dietary flavonoid, demonstrated anti-tumour effects in other tumour models, and is shown here to inhibit growth and induce caspase-dependent apoptosis of neuroblastoma cell lines in vitro. Apigenin upregulated p53 expression and activation prior to induction of apoptosis, and did not induce apoptosis in a p53-mutant cell line. Early changes in expression of genes regulating tumour cell survival and differentiation were also noted following exposure to apigenin. Furthermore, apigenin inhibited growth of subcutaneous tumours in a NOD/SCID mouse xenograft model of neuroblastoma. These observations suggest that apigenin is a potential agent for development for the treatment of neuroblastoma.