声明
ABSTRACT
摘要
Contents
Nomenclature
Chapter 1 Introduction
1．1 Literature review
1．2 Motivation
1．3 Research background and its significance
1．4 Research Objectives
1．5 The innovation of the thesis
1．6 Outline of the thesis
Chapter 2 Human Skin as a Barrier
2．1 Anatomy of the Skin
2．1．1 Epidermis
2．1．2 Epidermal-dermal junction
2．1．3 Dermis
2．1．4 Hypodermis(Subcutaneous layer)
2．2 Mechanical properties of the human skin
2．3 Skin changes
2．3．1 Skin aging
2．3．2 Skin diseases
2．4 Design of MN
2．5 Summary
Chapter 3 Numerical simulations of MNs
3．1．Optimization design of MN
3．1．1 Bending and compression force analysis
3．1．2 Force calculation method of MNs
3．2．Design of typical polymer MN
3．2．1．Bending force
3．2．2．Buckling force
3．3 Stress and strain analysis(ANSYS)MN
3．4．Determine the optimized MN size and polymer material
3．5 Summary
Chapter 4 Study of micro injection molding process of MN
4．1 Mold flow Analysis and Simulation
4．1．1 The impact of runner number on molding process and quality of product
4．1．2 Influence of MNs array structure on molding process and product quality
4．2 Manufacturing of MNs by micro injection molding process
4．2．1 Introduction to MIM
4．2．2 Experimental design
4．2．3 Experimental procedure
4．2．4 Machine and other equipment’s used
4．2．5 Taguchi experimentation and Minitab analysis
4．3 Summary
Chapter 5 study of hot embossing process of MNs
5．1 Selection of polymer materials
5．1．1 PMMA(Poly-methyl-meth-acrylate)
5．1．2 PLA(Polylactie acid)
5．1．3 PC(Polycarbonate)
5．2 Machine and other equipment’s used
5．2．1 Experimental machine
5．2．2 Embossing Mold
5．2．3 Measurements and Image Characterization
5．3Marginal effect and its improvement
5．3．1 Edge effect phenomenon
5．3．2 Measures to improve the edge effect
5．4 Experimental design
5．4．1 Experimental procedure
5．4．2 The Experimental Cycle
5．4．3 Taguchi analysis
5．5 Summary
Chapter 6 Testing of Polymer MN Products
6．1 In vitro assessment of polymer MNS
6．1．1 Mechanical Strength and Rupture of MNs
6．1．2 Penetration test of MNs
6．2 In vivo assessment of polymer MNS
6．3 Summary
Chapter 7 Conclusions and Outlook
7．1 Conclusions
7．2 Outlook
References
Acknowledgments
Author Publications
Author and Supervisor Information
