声明
Acknowledgement
摘要
ABSTRACT
List of Figures
List of Abbreviations
Table of Content
Chapter 1:Introduction
Chapter 2:Literature Review
2.1 Sources of Marine Antibiotics
2.1.1 Marine Invertebrates
2.1.2 Marine Microorganisms(Bacteria and Fungi)
2.2 Chemistry and Activities of Marine Antibiotics
2.2.1 Antibiotics in Protein/Polypeptide Class
2.2.2 Antibiotics in Polyketide/Macrolactones Class
2.2.3 Antibiotics in AnthrOquinone Class
2.2.4 Antibiotics in Terpenoid Class
2.2.5 Antibiotics in Alkaloid Class
2.3 Some Strategies to Isolate Unculturable Microorganisms,Unlock Cryptic Gene Clusters or Enhance Antibiotics Capacities against Resistant Strains
2.4 Aim and 0bjectives
Chapter 3:Stress-Driven Discovery of Novel Cryptic Antibiotics from a Marine Fungus Penicillium sp.BB1122
3.1 Materials and Methods
3.1.1 General Experimental Procedures
3.2 Isolation of the Fungal Strain
3.3 Normal and Metal-Stress Cultivation
3.3.1 Fermentation in Large Scale
3.4 Extraction,HPLC-Guided Isolation,and Identification of Stress Metabolites
3.5 Computation Section
3.6 Results and Discussion
3.6.1 Novel Compounds Elucidation
3.6.2 Known Compounds Elucidation
Chapter 4:Biological Activity,Cytotoxicity and PossibleMode of Action of Novel Cryptic Antibiotics from Penicillium sp.BB1122
4.1 Antibiotic Activity Screening of Stress Metabolites
4.1.1 Determination of MIC and MBC
4.1.2 Cytotoxicity Assay
4.2 Results ofBiological Activity and Cytotoxicity
4.3 Possible Mode of Action
Chapter 5:Conclusion
References
Appendix
Resume