ABSTRACT
前言
第一部分：大鼠三义神经节神经元5-羟色胺激活电流及其特征
1材料和方法
2结果
2.1 TG细胞5-HT激活电流
2.2 I5-HT的动力学特征
2.3 I5-HT浓度-反应曲线
2.4 I5-HT电流-电压(Ⅰ-Ⅴ)曲线
2.5 I5-HT不依赖G蛋白的存在
3讨论
参考文献
图注和图
第二部分：Potentiation of 5-HT3 receptor function by the activation of coexistent 5-HT2 receptors in trigeminal ganglion neurons of rats
1 Introduction
2 Materials and Methods
2.1 Isolation of TG neurons
2.2 Electrophysiological recordings
2.3 Drug application
2.4 Data analysis
3 Results
3.1Current mediated by 5-HT3 receptor subtype in rat TG neurons
3.2 Potentiation by α-methyl-5-HT of the current mediated by 5-HT3 receptor
3.3 Concentration-response relationship for I5-HT with and without α-methyl-5-HT pretreatment
3.4 Current-voltage relationship for I5-HT with and without α-methyl- 5-HT pretreatment
3.5 Intracellular signal transduction mechanism underlying potentiation of I5-HT by α-methyl-5-HT
3.6 Lack of modulory effect of R-(+)-UH-301 pretreatment on 5-HT3 receptor function
4 Discussion
References
Legends and figures
第三部分: Substance P potentiates 5-HT3 receptor mediated current in rattrigeminal ganglion neurons
1 Introduction
2 Materials and Methods
3 Results
3.1 Enhancement by SP preapplication of current mediated by5-HT3 receptor
3.2 Concentration-response and current-voltage relationships for5-HT with and without SP preapplication
3.3 Intracellular signal transduction mechanism underlying SPpotentiation of I5-HT
4 Discussion
References
Legends and figures
第四部分：SP对大鼠三叉神经节神经元GABA-和5-HT-激活电流的反向调制作用
1材料和方法
2结果
2.1由TG细胞所记录的IGABA和I5-HT
2.2 SP对同一TG细胞IGABA和I5-HT的反向调制作用
2.3 SP调制IGABA和I5-HT的胞内信号转导机制分析
3讨论
参考文献
图注和图
第五部分：Inhibition by bis(7)-tacrine of nicotinic ACh receptor mediatedcurrent in rat trigeminal ganglion neurons
1 Introduction
2 Materials and Methods
3 Results
3.1 nAChR mediated current in rat TG neurons
3.2 Comparison between inhibition of IAch by coapplication of bis(7)-tacrine and that by coapplication of tacrine
3.3 Concentration-response relationship for ACh with and without coapplication of bis(7)-tacrine
3.4 Current-voltage relationship for IAch with and without bis(7)-tacrine coapplication
3.5 The G-protein independence of bis(7)-tacrine inhibition on IACh
4 Discussion
5 Conclusion
References
Legends and figures
第六部分：Potentiation by aluminum of currents mediated by nicotinic ACh receptor in rat trigeminal ganglion neurons
1 Introduction
2 Materials and Methods
3 Results
3.1 nAChR mediated currents in rat TG neurons
3.2 Potentiation of INic by aluminum
3.3 Concentration-response relationship for nicotine with and without coapplication of aluminum
3.4 Effect of membrane potential on the potentiation of INic by aluminum
4 Discussion
References
Legends and figures
小结
综述：5-HT受体与疼痛
一、5-HT受体
二、5-HT受体分布
三、5-HT受体的疼痛
参考文献
附录：攻读博士学位期间发表的论文
致谢
