Neutron capture therapy of murine melanoma on new boron carriers with use of capillary neutron optics

摘要

The Boron-10 NCT is one of the most perspective methods of human anticancer treatment. The introduction of this efficient method into medical practice makes possible more selective and precise destruction of tumour cells without any damage of normal tissues. The basis of NCT method is destructive effect of products of nuclear reaction ~(10)B(n,α,γ)~7Li. This reaction produces particles - helium nuclei (alpha-particles) and lithium nuclei - with too high linear energetic loss in animal tissues and poor integrated sweep (to 14 μm) what is comparable with single cell diameter. Actual use of BNCT for treatment of human malignant tumours is dependent on resolution of various and complex scientific and technical problems. Namely: the development of novel boron preparations selectively carrying ~(10)B into cancer cells, providing optimal concentration and microdistribution of ~(10)B in these and remaining there during all necessary irradiation time; formation of therapeutic neutron fluxes of needed power, spectrum and intensity; provision of adequate planning and monitoring methods for current ~(10)B -NCT making possible to evaluate a boron concentration in animal tissues in real time, to see macro- and microdistribution of the same, allowing precise microdosimetry; optimization of irradiation regimens and of drug administration schedules conformably to concrete neutron flux in different objects.