Contributions to the research of neuromuscular excitability and thermo-algesic sensibility in the chronic experimental exposure of aluminium administered in the drinking water

摘要

Aluminium is being actively investigated as a metal relevant to neurological disorders. Because previous research regarding the concentration of Al in drinking water of different surface sources from Iassy territory where there are put in evidence frequently, medium maximal concentration of 0,35 mg/l (C.M.A.= 0,2 mg/l) it was imposed this chronic experiment with doses of aluminium sulphate calculated in relation with animal body weight or normal exposure frequency (people-animal) at the drinking water. The electophysiologica! experiment was made on 30 male Wistar rats divided in 3 equal groups: a control group and 2 other groups that received orally, in food, for 90 days, as a sulphate 0,125 mgAl/Kg body, for lot 1, and 1,2 mgAl/Kg body. The neuromuscles excitability was investigated by cronaxymetrical method and thermoalgezyc sensibility by tail-flick method. Al administrated in the water as a sulphate has determined modifications of the neuromuscles excitability and of the thermo-algesic sensibility.