NOVEL POLYMERIC COATINGS FOR CONTROLLED DRUG RELEASE

摘要

The recent FDA approval of a polystyrene-b-polyisobutylene-b-polystyrene block copolymer (SIBS), used as the drug-eluting polymeric coating on the Taxus? coronary stent, opened new avenues for poyisobutylene (PIB)-based biomaterials. SIBS was invented at the University of Akron, and is now commercially produced or test marketed (Kaneka Co., BASF). SIBS has unique combination of properties, and is precision synthesized by living carbocationic polymerization. The latest member of the family of these novel materials has a dendritic core (SDIBS) and is synthesized by inimer-type living polymerization. The properties of SDIBS depend on its composition, molecular weight and architecture. Dexamethasone (DM) is an alternative to the paclitaxel used on Taxus?. DM/SDIBS were spray-coated onto stents. Depending on the properties of SDIBS and spraying conditions, smooth or various nanostructured films were obtained. This lecture will discuss how the morphology of these coatings affected drug release profiles.