STRUCTURE-BASED VACCINE DESIGN: LESSONS FROM RSV F

摘要

The use of atomic-level information in the design of immunogens has created new candidate vaccines against important pathogens. From our work on the fusion glycoprotein from respiratory syncytial virus (RSV), we have learned several important lessons that may be generally applicable to other structure-based vaccine-design efforts. This talk will summarize these lessons and the latest advances in the field, as well as highlight opportunities for future development.