211At-Rh(16-S4-diol) complex as a precursor for astatine radiopharmaceuticals

摘要

The binding of 211At- anion to complex of Rh3+ with thioether ligand: 1,5,9,13-rntetrathiacyclohexadecane-3,11-diol (16-S4-diol) was investigated in aqueous – ethanolic solutions.rnDue to limited availability of 211At the experiments related to optimization of reaction conditions werernperformed with 131I isotope. The obtained complexes were characterized by paper electrophoresis, ion–rnexchange methods, thin layer chromatography (TLC) and adsorption on MgO. It was found that iodidernand astatide studied complexes are cationic, where sulfur donor atoms of 16-S4-diol ligand occupyrnequatorial positions and 211At (131I) and OH- are in axial positions. The obtained iodide complexrnexhibit high stability even during incubation for more than 2 days at 37℃.