Preliminary Study on Pathogenic Mechanism of Obsessive-Compulsive Disorder

摘要

OCD manifested obviously abnormal personality and immature defensive orientation. It suggested psychogenetics play an important role in OCD. OCD and other anxiety disorders expressed quite different in platelet serotonin level. It challenges the hypothesis that OCD is one kind of anxiety disorders. DST and the prolactin test showed no specific on OCD patients. There was some significant difference among items of BEP in OCD and other three controls, but need to identify their clinical meaning. The blood flow of OCD in most parts of right cortex were higher than the left one, and the subcortical structure has opposite orientation. Especially, the blood flow in left temporo-occipital of OCD was significant lower to normal control. Comparing between the subtype of symptoms-Obsessive and compulsive, as well as between the subtype of positive or negative psychiatric family history, no significant difference were found among different dimensions. Suggested that no definite evidence support the heterogeneity hypothesis of OCD.