REGENERATED CONTRACTING MYOCARDIUM MAY IMPROVE POST-SURGERY RIGHT VENTRICLE FUNCTION: PATCH COMPARISON USING MRI-BASED TWO-LAYER ANISOTROPIC MODELS OF HUMAN RIGHT AND LEFT VENTRICLES

摘要

Patients with repaired Tetralogy of Fallot (ToF), a congenital heart defect which includes a ventricular septal defect and severe right ventricular outflow obstruction, account for the majority of cases with late onset RV failure. The current surgical approach, which includes pulmonary valve replacement/insertion (PVR), has yielded mixed results. One reason for the unpredictable results is that the PVR surgery only addresses pulmonary regurgitation. New surgical options including scar tissue reduction and RV remodeling have been proposed in order to improve RV function recovery [1]. Various RV