Design Optimization of a Wearable Artificial Pump-Lung Device With Computational Modeling

摘要

The heart-lung machine has been commonly used to replace or supplement the functions of both the heart and lung in the open heart surgery and extracorporeal membrane oxygenation (ECMO). Although ECMO devices are efficient on respiratory support, this traditional system consists of multiple components and is bulky. Furthermore, ECMO devices are associated with clinical complications as well as the necessity of being confined to the bed. To eliminate these, we aimed to design and develop a wearable artificial pump lung (APL) device.rnAPL will integrate the blood pumping and oxygenation into a single and compact unit for cardiopulmonary or respiratory support for patients suffering from cardiac failure or respiratory failure or both and to allow patients to be ambulatory. To this end, a wearable APL device is being developed by integrating of a magnetically levitated centrifugal rotor/impeller with hollow fiber membranes to achieve both blood pumping and gas transfer (Fig.l).rnWe have initially conducted a CFD assisted design study of the device, and determined the suitable design among several different configurations of outer housing and impeller structures while targeting a full respiratory support (200-250 ml/min gas exchange that the natural lung delivers under the resting condition) [1]. In this current work, we extended the previous work including different configurations while targeting to provide a partial respiratory support (≥150 ml/min gas exchange).