Mechano-Active Cartilage Tissue Engineering: Effects of Biomechanical Conditioning

摘要

In this study, it was tested that the proper compressive deformation induces the phenotype of chondrocytes in engineered tissues in vitro to be similar to that of chondrocytes in native tissues in vivo. As a result, by the mechanical stimulation for 10 days, cell-polymer constructs formed mature and well-developed cartilaginous tissue, as evidenced by chondrocytes within lacunae and accumulated sul fated GAGs. In conclusion, the proper periodic application of dynamic compression can encourage chondrocytes to maintain their phenotypes and enhance GAGs production and consequently, improve the quality of cartilaginous tissue formed in vitro and in vivo.