Cysteine-containing Polypeptides Allow Control over Various Properties of Biodegradable Multilayer Nanofilms

摘要

Differences in assembly behavior and disassembly behavior must be attributable to differences in amino acid sequence. Disulfide crosslinks stabilize polypeptide multilayer films, similar to how they stabilize native protein structure. Free thiols could also be useful for stimulated release of thiol-containing compounds in a reducing environment. Polypeptide films are biodegradable. Other biological properties, for instance immunogenicity, will depend on sequence (Zheng et al., 2005). Polypeptide multilayer films are promising for biomaterials development.