Decellularized Human Vocal Fold as a Scaffold for Laryngeal Tissue Engineering

摘要

We have developed a naturally derived scaffold from human vocal fold tissue that preserves the Young's modulus, collagen, elastin, and laminin._Because the above characteristics are important for vocal fold function, these results are promising for its tissue engineering applications. Plans for the immediate future include further characterization of the scaffold (e.g. quantifying DNA before and after decellularization), reseeding the scaffold with adipose-derived stem cells, and testing the scaffold's phonation properties.