Osteogenic differentiation of mesenchymal stem cells on demineralized and devitalized biodegradable polymer and extracellular matrix hybrid constructs

摘要

This study explored the effect of devitalization and demineralization techniques on the retention of ECM components within cell-generated ECM coated constructs and the osteogenic differentiation of MSCs seeded onto these constructs. Overall, the methods applied in the processing of cell-generated ECM coated constructs were found to impact the composition and associated osteoeenicity of the constructs.