Decellularized Extracellular Matrix Microparticles Support Fibroblast and Mesenchymal Stem Cell Growth and are a Vehicle for Cellular Delivery in a Model of Anastomosis Healing

摘要

This study demonstrates the feasibility of fibroblast and MSC seeding and culture on microparticle bits of decellularized ECM derived from porcine mesothelium. Fibroblasts robustly migrate off the bits within carrier gels and can transfer to an adjacent anastomosis model. The fibroblasts when delivered in sufficient quantity from the bits can strengthen the anastomotic model. This approach of delivering cells to a surgical site on bits for direct mechanical and paracrine benefit may be a potential gateway to innovative therapies for a wide variety of surgical treatments.