Modulation of microRNAs for Treatment of Glioblastoma Multiforme

摘要

Cationic liposomal delivery of miR effectively targets cells of interest with minimal cytotoxicity due to liposomes alone. Delivering miRs in combination to reduce the cells anti-apoptotic properties and in the meantime increase the miRNA that promotes apoptosis is an effective treatment regime to induce apoptosis and retard the growth progression of the tumor. In our future studies we plan to deliver these miRs in combination in an in vivo rodent model.