Fibrous Scaffolds from Elastomeric Biodegradable PLCL for Cardiovascular Tissue Engineering

摘要

This preliminary study to assess the suitability of converting elastomeric PLCL copolymers into fibers via melt spinning and/or electrospinning has shown promising results. By combining melt spinning with electrospinning, it will be possible to vary surface porosity with sufficient mechanical strength. For future work, the scaffold will be melt spun as a tubular mandrel and nanofibers will be formed around the mandrel to promote large surface area via electrospinning. The morphology, porosity and mechanical properties of the tubular scaffolds will be evaluated and the rate of resorption in vitro will be investigated prior to cell culture studies.