Nanostructural control of the release of opioids prevents their abuse

摘要

The novel sol gel controlled release technology offers a fundamental solution to the abuse issue of controlled release opioid tablets. The controlled release materials can be made as monoliths which cannot be crushed to sizes smaller than about 10 μm. This size is then still three orders of magnitude larger than the pore channels (about 2 nm) that can be created to contain the opioid.